Human CLCN3 protein (Recombinant) (N-His) (STJP016218)

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STJP016218
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Short Description :Recombinant-Human CLCN3-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:CLCN3
Gene ID:1182
Uniprot ID:CLCN3_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Glu646-Asn818
Post Translational Modifications N-glycosylated.
Function Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.
Protein Name H(+/Cl(- Exchange Transporter 3
Chloride Channel Protein 3
Clc-3
Chloride Transporter Clc-3
Database Links Reactome: R-HSA-2672351
Cellular Localisation Isoform 1: Early Endosome Membrane
Multi-Pass Membrane Protein
Late Endosome Membrane
Lysosome Membrane
Cell Membrane
Isoform 1 Is Localized Mainly In Late Endosomes
Isoform 2: Golgi Apparatus Membrane
Cell Projection
Ruffle Membrane
Isoform 2 Is Mainly Enriched In The Golgi
Colocalizes With Nherf1/Ebp50 In Membrane Ruffles
Alternative Protein Names H(+/Cl(- Exchange Transporter 3 protein
Chloride Channel Protein 3 protein
Clc-3 protein
Chloride Transporter Clc-3 protein
CLCN3 protein

Information sourced from Uniprot.org

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