| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as 0.22 Mu m filtered solution in PBS (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant. |
| Storage Instruction: | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CLDN4 |
| Gene ID: | 1364 |
| Uniprot ID: | CLD4_HUMAN |
| Immunogen Region: | Met1-Val209 |
| Immunogen: | Recombinant Human Claudin-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Val209) of human Claudin-4 (Accession #NP_001296.1 ) fused with no additional amino acid. |
| Immunogen Sequence: | MASMGLQVMGIALAVLGWLA VMLCCALPMWRVTAFIGSNI VTSQTIWEGLWMNCVVQSTG QMQCKVYDSLLALPQDLQAA RALVIISIIVAALGVLLSVV GGKCTNCLEDESAKAKTMIV AGVVFLLAGLMVIVPVSWTA HNIIQDFYNPLVASGQKREM GASLYVGWAASGLLLLGGGL LCCNCPPRTDKPYSAKYSAA RSAAASNYV |
| Post Translational Modifications | Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1. |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-4Clostridium Perfringens Enterotoxin ReceptorCpe-RCpe-ReceptorWilliams-Beuren Syndrome Chromosomal Region 8 Protein |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Claudin-4 proteinClostridium Perfringens Enterotoxin Receptor proteinCpe-R proteinCpe-Receptor proteinWilliams-Beuren Syndrome Chromosomal Region 8 Protein proteinCLDN4 proteinCPER proteinCPETR1 proteinWBSCR8 protein |
Information sourced from Uniprot.org