Human CISH protein (Recombinant) (N-His) (STJP006087)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CISH-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CISH |
| Gene ID | 1154 |
| Uniprot ID | CISH_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Leu258 |
Additional Info
| Post Translational Modifications | Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa). |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Cytokine-Inducible Sh2-Containing ProteinCisCis-1Protein G18Suppressor Of Cytokine SignalingSocs |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8951664Reactome: R-HSA-982772 |
| Cellular Localisation | |
| Alternative Protein Names | Cytokine-Inducible Sh2-Containing Protein proteinCis proteinCis-1 proteinProtein G18 proteinSuppressor Of Cytokine Signaling proteinSocs proteinCISH proteinG18 protein |
Information sourced from Uniprot.org