| Post Translational Modifications | Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa). |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Cytokine-Inducible Sh2-Containing ProteinCisCis-1Protein G18Suppressor Of Cytokine SignalingSocs |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8951664Reactome: R-HSA-982772 |
| Alternative Protein Names | Cytokine-Inducible Sh2-Containing Protein proteinCis proteinCis-1 proteinProtein G18 proteinSuppressor Of Cytokine Signaling proteinSocs proteinCISH proteinG18 protein |
Information sourced from Uniprot.org
