Name: Human CILK1 protein (Recombinant) (N-His) (STJP006219)
SKU: STJP006219
Availability: InStock

Human CILK1 protein (Recombinant) (N-His) (STJP006219)

SKU:

STJP006219

£328.50 - £1,437.50

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human CILK1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 increases kinase activity.
Function	Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
Protein Name	Serine/Threonine-Protein Kinase Ick Ciliogenesis Associated Kinase 1 Intestinal Cell Kinase Hick Laryngeal Cancer Kinase 2 Lck2 Mak-Related Kinase Mrk
Cellular Localisation	Nucleus Cytoplasm Cytosol Cell Projection Cilium Cytoskeleton Cilium Basal Body Also Found At The Ciliary Tip Nuclear Localization Has Been Observed With A Gfp-Tagged Construct In Transfected Hela Cells Isoform 2: Cytoplasm Predominant Cytoplasmic Localization Has Been Observed With A N-Terminally Gfp-Tagged Construct
Alternative Protein Names	Serine/Threonine-Protein Kinase Ick protein Ciliogenesis Associated Kinase 1 protein Intestinal Cell Kinase protein Hick protein Laryngeal Cancer Kinase 2 protein Lck2 protein Mak-Related Kinase protein Mrk protein CILK1 protein ICK protein KIAA0936 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP002980	Human KLHL20 protein (Recombinant) (N-His) (STJP002980)	HEK293 cells
STJP003027	Human CCL3L1 protein (Recombinant) (N-His) (STJP003027)	HEK293 cells
STJP003488	Human CFD protein (Recombinant) (N-His) (STJP003488)	E. coli

Human CILK1 protein (Recombinant) (N-His) (STJP006219)

General Information