Human CIAPIN1 protein (Recombinant) (His-Tag) (STJP018037)

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STJP018037
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CIAPIN1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CIAPIN1
Gene ID: 57019
Uniprot ID: CPIN1_HUMAN
Immunogen Region: 1-312aa
Accession Number: NP_064709
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMADFGIS AGQFVAVVWD KSSPVEALKG LVDKLQALTG NEGRVSVENI KQLLQSAHKE SSFDIILSGL VPGSTTLHSA EILAEIARIL RPGGCLFLKE PVETAVDNNS KVKTASKLCS ALTLSGLVEV KELQREPLTP EEVQSVREHL GHESDNLLFV QITGKKPNFE VGSSRQLKLS ITKKSSPSVK PAVDPAAAKL WTLSANDM
Tissue Specificity Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
Function Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a 4Fe-4S cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
Protein Name Anamorsin
Cytokine-Induced Apoptosis Inhibitor 1
Fe-S Cluster Assembly Protein Dre2 Homolog
Database Links Reactome: R-HSA-2564830
Cellular Localisation Cytoplasm
Nucleus
Mitochondrion Intermembrane Space
Alternative Protein Names Anamorsin protein
Cytokine-Induced Apoptosis Inhibitor 1 protein
Fe-S Cluster Assembly Protein Dre2 Homolog protein
CIAPIN1 protein
CUA001 protein
PRO0915 protein

Information sourced from Uniprot.org

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