Human CHST15 (Human Carbohydrate Sulfotransferase 15) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014321)
SPECIFICATIONS
General Information
| Short Description | This CHST15 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 18.8pg/mL |
| Detection Limit | 39.6-2500pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | CHST15 |
| Gene ID | 51363 |
| Uniprot ID | CHSTF_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1. |
| Post Translational Modifications | Glycosylated. |
| Function | Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression.however such results are unclear in vivo. |
| Protein Name | Carbohydrate Sulfotransferase 15B-Cell Rag-Associated Gene ProteinHbragN-Acetylgalactosamine 4-Sulfate 6-O-SulfotransferaseGalnac4s-6st |
| Database Links | Reactome: R-HSA-2022870 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinA Small Fraction May Also Be Present At The Cell SurfaceWhere It Acts As A B-Cell Receptor |
| Alternative ELISA Names | Carbohydrate Sulfotransferase 15 ELISA kitB-Cell Rag-Associated Gene Protein ELISA kitHbrag ELISA kitN-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase ELISA kitGalnac4s-6st ELISA kitCHST15 ELISA kitBRAG ELISA kitGALNAC4S6ST ELISA kitKIAA0598 ELISA kit |
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Information sourced from Uniprot.org