| Post Translational Modifications | Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors. Cleaved by BACE1. N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). O-glycosylated. |
| Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. |
| Protein Name | Neural Cell Adhesion Molecule L1-Like ProteinClose Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein |
| Database Links | Reactome: R-HSA-447041 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Forms Produced By Cleavage/Shedding Also ExistProcessed Neural Cell Adhesion Molecule L1-Like Protein: SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Neural Cell Adhesion Molecule L1-Like Protein proteinClose Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein proteinCHL1 proteinCALL protein |
Information sourced from Uniprot.org
