Human CFL2 protein (Recombinant) (N-His) (STJP006325)

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STJP006325
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CFL2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CFL2
Gene ID: 1073
Uniprot ID: COF2_HUMAN
Immunogen Region: Met1-Asn156
Immunogen: Homo sapiens (Human)
Post Translational Modifications The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.
Protein Name Cofilin-2
Cofilin - Muscle Isoform
Cellular Localisation Nucleus Matrix
Cytoplasm
Cytoskeleton
Colocalizes With Cspr3 In The Z Line Of Sarcomeres
Alternative Protein Names Cofilin-2 protein
Cofilin - Muscle Isoform protein
CFL2 protein

Information sourced from Uniprot.org

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