Human CFI protein (Recombinant) (N-His) (STJP003709)

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STJP003709
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CFI-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CFI
Gene ID: 3426
Uniprot ID: CFAI_HUMAN
Immunogen Region: Lys19-Ile335
Immunogen: Homo sapiens (Human)
Function Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.
Protein Name Complement Factor I
C3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain
Database Links Reactome: R-HSA-977606
Cellular Localisation Secreted
Extracellular Space
Alternative Protein Names Complement Factor I protein
C3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain protein
CFI protein
IF protein

Information sourced from Uniprot.org

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