| Short Description : | Recombinant-Active-Human CES2-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to hydrolyze pnitrophenylacetate. The specific activity is >30, 000 pmol/min/Mu g, measured under the described conditions. |
| Gene Symbol: | CES2 |
| Gene ID: | 8824 |
| Uniprot ID: | EST2_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Gln27-Leu559 |
| Post Translational Modifications | Glycosylated. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. |
| Protein Name | Cocaine EsteraseCarboxylesterase 2Ce-2Hce-2Methylumbelliferyl-Acetate Deacetylase 2 |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Protein Names | Cocaine Esterase proteinCarboxylesterase 2 proteinCe-2 proteinHce-2 proteinMethylumbelliferyl-Acetate Deacetylase 2 proteinCES2 proteinICE protein |
Information sourced from Uniprot.org