Human CES1 protein (Recombinant) (N-His) (STJP006596)

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STJP006596
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CES1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CES1
Gene ID: 1066
Uniprot ID: EST1_HUMAN
Immunogen Region: Gly18-Leu299
Immunogen: Homo sapiens (Human)
Post Translational Modifications Contains sialic acid. Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
Protein Name Liver Carboxylesterase 1
Acyl-Coenzyme A -Cholesterol Acyltransferase
Acat
Brain Carboxylesterase Hbr1
Carboxylesterase 1
Ce-1
Hce-1
Cholesteryl Ester Hydrolase
Ceh
Cocaine Carboxylesterase
Egasyn
Hmse
Methylumbelliferyl-Acetate Deacetylase 1
Monocyte/Macrophage Serine Esterase
Retinyl Ester Hydrolase
Reh
Serine Esterase 1
Triacylglycerol Hydrolase
Tgh
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-211945
Reactome: R-HSA-5578768
Reactome: R-HSA-9749641
Cellular Localisation Endoplasmic Reticulum Lumen
Cytoplasm
Lipid Droplet
Moves From Cytoplasm To Lipid Droplets Upon Lipid Loading
Associates With Lipid Droplets Independently Of Triglycerides (Tg) Content Of The Droplets And Hydrolyzes Cholesteryl Esters More Efficiently From Mixed Droplets
Alternative Protein Names Liver Carboxylesterase 1 protein
Acyl-Coenzyme A -Cholesterol Acyltransferase protein
Acat protein
Brain Carboxylesterase Hbr1 protein
Carboxylesterase 1 protein
Ce-1 protein
Hce-1 protein
Cholesteryl Ester Hydrolase protein
Ceh protein
Cocaine Carboxylesterase protein
Egasyn protein
Hmse protein
Methylumbelliferyl-Acetate Deacetylase 1 protein
Monocyte/Macrophage Serine Esterase protein
Retinyl Ester Hydrolase protein
Reh protein
Serine Esterase 1 protein
Triacylglycerol Hydrolase protein
Tgh protein
CES1 protein
CES2 protein
SES1 protein

Information sourced from Uniprot.org

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