| Post Translational Modifications | Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation. Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity. |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions. |
| Protein Name | Ceramide Synthase 2Cers2Lag1 Longevity Assurance Homolog 2Sp260Sphingosine N-Acyltransferase Cers2Tumor Metastasis-Suppressor Gene 1 ProteinVery-Long-Chain Ceramide Synthase Cers2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Ceramide Synthase 2 proteinCers2 proteinLag1 Longevity Assurance Homolog 2 proteinSp260 proteinSphingosine N-Acyltransferase Cers2 proteinTumor Metastasis-Suppressor Gene 1 Protein proteinVery-Long-Chain Ceramide Synthase Cers2 proteinCERS2 proteinLASS2 proteinTMSG1 protein |
Information sourced from Uniprot.org
