| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM3 at 1 Mu g/mL (100 Mu L/well) can bind CEACAM3 Mouse mAb with a linear range of 0.1-2.7 ng/mL. |
| Gene Symbol: |
CEACAM3 |
| Gene ID: |
1084 |
| Uniprot ID: |
CEAM3_HUMAN |
| Immunogen: |
Recombinant Human CEACAM3/CD66d Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly155) of human CEACAM3/CD66d (Accession #NP_001806.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
MGPPSASPHRECIPWQGLLL TASLLNFWNPPTTAKLTIES MPLSVAEGKEVLLLVHNLPQ HLFGYSWYKGERVDGNSLIV GYVIGTQQATPGAAYSGRET IYTNASLLIQNVTQNDIGFY TLQVIKSDLVNEEATGQFHV YQENAPGLPVGAVAG |
| Tissue Specificity | CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. |
| Post Translational Modifications | Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. |
| Function | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. |
| Protein Name | Cell Adhesion Molecule Ceacam3Carcinoembryonic Antigen Cgm1Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3Cea Cell Adhesion Molecule 3Cd Antigen Cd66d |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam3 proteinCarcinoembryonic Antigen Cgm1 proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 3 proteinCea Cell Adhesion Molecule 3 proteinCd Antigen Cd66d proteinCEACAM3 proteinCD66D proteinCGM1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
