• Biotinylated Human CEACAM-6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human CEACAM-6 is greater than 95% as determined by SEC-HPLC.
  • Human CEACAM-8, His Tag immobilized on CM5 Chip can bind Biotinylated Human CEACAM6, His-Avi Tag with an affinity constant of 3. 81 Mu M as determined in SPR assay (Biacore T200).

Human CEACAM-6/CD66c protein (Recombinant) (C-His-Avi) {Biotin} (STJP001657)

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STJP001657

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CEACAM-6/CD66c-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CEACAM6
Gene ID: 4680
Uniprot ID: CEAM6_HUMAN
Immunogen Region: Lys35-Gly320
Immunogen: DNA sequence encoding Human CEACAM-6/CD66c including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Glycosylated.
Function Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role as an oncogene by promoting tumor progression.positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells.
Protein Name Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6
Non-Specific Crossreacting Antigen
Normal Cross-Reacting Antigen
Cd Antigen Cd66c
Database Links Reactome: R-HSA-1566977
Reactome: R-HSA-202733
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Cell Surface
Localized To The Apical Glycocalyx Surface
Alternative Protein Names Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 protein
Non-Specific Crossreacting Antigen protein
Normal Cross-Reacting Antigen protein
Cd Antigen Cd66c protein
CEACAM6 protein
NCA protein

Information sourced from Uniprot.org

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