| Short Description : | Recombinant-Human CDK3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact us for further information. |
| Gene Symbol: | CDK3 |
| Gene ID: | 1018 |
| Uniprot ID: | CDK3_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Met1-His305 |
| Function | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle.involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| Protein Name | Cyclin-Dependent Kinase 3Cell Division Protein Kinase 3 |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Cyclin-Dependent Kinase 3 proteinCell Division Protein Kinase 3 proteinCDK3 proteinCDKN3 protein |
Information sourced from Uniprot.org
