Human CDK16 protein (Recombinant) (His-Tag) (STJP018523)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CDK16-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDK16 |
| Gene ID | 5127 |
| Uniprot ID | CDK16_HUMAN |
| Accession Number | NP_006192 |
| Immunogen | Human |
| Immunogen Region | 158-496aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in pancreas islets (at protein level). Detected in brain and pancreas. |
| Post Translational Modifications | Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity. Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity. Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity. Phosphorylation at Ser-153 inhibits kinase activity. |
| Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). |
| Protein Name | Cyclin-Dependent Kinase 16Cell Division Protein Kinase 16Pctaire-Motif Protein Kinase 1Serine/Threonine-Protein Kinase Pctaire-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic VesicleSecretory VesicleCell MembranePeripheral Membrane ProteinCytoplasmic SideSynapseSynaptosomeColocalizes With Insulin In Pancreas IsletsRecruited To The Cell Membrane By Ccny |
| Alternative Protein Names | Cyclin-Dependent Kinase 16 proteinCell Division Protein Kinase 16 proteinPctaire-Motif Protein Kinase 1 proteinSerine/Threonine-Protein Kinase Pctaire-1 proteinCDK16 proteinPCTAIRE1 proteinPCTK1 protein |
Information sourced from Uniprot.org