| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CDH5/VE-cadherin-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Gene Symbol: |
CDH5 |
| Gene ID: |
1003 |
| Uniprot ID: |
CADH5_HUMAN |
| Immunogen: |
Recombinant Human CDH5/VE-cadherin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp48-Gln593) of human VE-Cadherin (Accession #NP_001786.2) fused with an Fc, 6×His tag at the C-terminus. |
| Tissue Specificity | Endothelial tissues and brain. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. |
| Protein Name | Cadherin-57b4 AntigenVascular Endothelial CadherinVe-CadherinCd Antigen Cd144 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920 |
| Cellular Localisation | Cell JunctionCell MembraneSingle-Pass Type I Membrane ProteinFound At Cell-Cell Boundaries And Probably At Cell-Matrix BoundariesKrit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions |
| Alternative Protein Names | Cadherin-5 protein7b4 Antigen proteinVascular Endothelial Cadherin proteinVe-Cadherin proteinCd Antigen Cd144 proteinCDH5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
