Human CD93 protein (Recombinant) (C-Fc) (STJP015539)

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STJP015539
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Short Description :Recombinant-Human CD93-C-Fc protein was developed from mammalian cells for the region C-Fc. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:CD93
Gene ID:22918
Uniprot ID:C1QR1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Lys580
Post Translational Modifications N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration.
Function Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function.
Protein Name Complement Component C1q Receptor
C1q/Mbl/Spa Receptor
C1qr
C1qr(P
C1qrp
Cdw93
Complement Component 1 Q Subcomponent Receptor 1
Matrix-Remodeling-Associated Protein 4
Cd Antigen Cd93
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Complement Component C1q Receptor protein
C1q/Mbl/Spa Receptor protein
C1qr protein
C1qr(P protein
C1qrp protein
Cdw93 protein
Complement Component 1 Q Subcomponent Receptor 1 protein
Matrix-Remodeling-Associated Protein 4 protein
Cd Antigen Cd93 protein
CD93 protein
C1QR1 protein
MXRA4 protein

Information sourced from Uniprot.org

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