Biotinylated Human CD93 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human CD93/C1q R1 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001565)

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STJP001565
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Covered by St John's Laboratory Guarantee

Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD93/C1q R1-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CD93
Gene ID: 22918
Uniprot ID: C1QR1_HUMAN
Immunogen Region: Thr22-Lys580
Immunogen: DNA sequence encoding Human CD93/C1q R1 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration.
Function Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function.
Protein Name Complement Component C1q Receptor
C1q/Mbl/Spa Receptor
C1qr
C1qr(P
C1qrp
Cdw93
Complement Component 1 Q Subcomponent Receptor 1
Matrix-Remodeling-Associated Protein 4
Cd Antigen Cd93
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Complement Component C1q Receptor protein
C1q/Mbl/Spa Receptor protein
C1qr protein
C1qr(P protein
C1qrp protein
Cdw93 protein
Complement Component 1 Q Subcomponent Receptor 1 protein
Matrix-Remodeling-Associated Protein 4 protein
Cd Antigen Cd93 protein
CD93 protein
C1QR1 protein
MXRA4 protein

Information sourced from Uniprot.org

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