Human CD91/LRP1 protein (Recombinant) (N-His) (STJP005224)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD91/LRP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LRP1 |
| Gene ID | 4035 |
| Uniprot ID | LRP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala20-His280 |
Additional Info
| Post Translational Modifications | Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1. |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Also acts as a receptor for IGFBP3 to mediate cell growth inhibition. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. |
| Protein Name | Prolow-Density Lipoprotein Receptor-Related Protein 1Lrp-1Alpha-2-Macroglobulin ReceptorA2mrApolipoprotein E ReceptorApoerCd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda SubunitLrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda SubunitLrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular DomainLrpicd |
| Database Links | Reactome: R-HSA-2168880Reactome: R-HSA-975634 |
| Cellular Localisation | Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell MembraneSingle-Pass Type I Membrane ProteinMembraneCoated PitLow-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell MembranePeripheral Membrane ProteinExtracellular SideLow-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: CytoplasmNucleusAfter CleavageThe Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The NucleusGolgi OutpostCytoplasmCytoskeletonMicrotubule Organizing CenterLocalizes To The Postsynaptic Golgi Apparatus RegionAlso Named Golgi OutpostWhich Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation |
| Alternative Protein Names | Prolow-Density Lipoprotein Receptor-Related Protein 1 proteinLrp-1 proteinAlpha-2-Macroglobulin Receptor proteinA2mr proteinApolipoprotein E Receptor proteinApoer proteinCd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit proteinLrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit proteinLrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain proteinLrpicd proteinLRP1 proteinA2MR proteinAPR protein |
Information sourced from Uniprot.org