Human CD83 protein (Recombinant) (His-Tag) (STJP018032)

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STJP018032
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD83-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD83
Gene ID: 9308
Uniprot ID: CD83_HUMAN
Immunogen Region: 20-144aa
Accession Number: NP_001035370
Immunogen: Human
Immunogen Sequence: TPEVKVA CSEDVDLPCT APWDPQVPYT VSWVKLLEGG EERMETPQED HLRGQHYHQK GQNGSFDAPN ERPYSLKIRN TTSCNSGTYR CTLQDPDGQR NLSGKVILRV TGCPAQRKEE TFKKYRAE
Tissue Specificity Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells.
Post Translational Modifications Glycosylated when expressed on activated dendritic cells.
Function Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections.
Protein Name Cd83 Antigen
Hcd83
B-Cell Activation Protein
Cell Surface Protein Hb15
Cd Antigen Cd83
Database Links
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cd83 Antigen protein
Hcd83 protein
B-Cell Activation Protein protein
Cell Surface Protein Hb15 protein
Cd Antigen Cd83 protein
CD83 protein

Information sourced from Uniprot.org

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