Human CD6 protein (Recombinant-Active) (C-His) (STJP011963)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD6-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by the ability of the Immobilised protein to support the adhesion of human acute T cell leukemia cells (Jurkat). When 8×10^4 cells/well are added to CD6 coated plates (5 Mu g/mL and 100 Mu L/well) in the presence of 10 Mu g/ml PHA, approxima |
Target Information
| Gene Symbol | CD6 |
| Gene ID | 923 |
| Uniprot ID | CD6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His18-Glu398 |
Additional Info
| Post Translational Modifications | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated. |
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. |
| Protein Name | T-Cell Differentiation Antigen Cd6T12Tp120Cd Antigen Cd6 Cleaved Into - Soluble Cd6 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With The Tcr/Cd3 Complex At The Immunological SynapseSoluble Cd6: SecretedThe Origins Of The Secreted Form Are Not ClearBut It Might Be Created By Proteolytic Shedding Of The Ectodomain |
| Alternative Protein Names | T-Cell Differentiation Antigen Cd6 proteinT12 proteinTp120 proteinCd Antigen Cd6 Cleaved Into - Soluble Cd6 proteinCD6 protein |
Information sourced from Uniprot.org