| Post Translational Modifications | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated. |
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. |
| Protein Name | T-Cell Differentiation Antigen Cd6T12Tp120Cd Antigen Cd6 Cleaved Into - Soluble Cd6 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With The Tcr/Cd3 Complex At The Immunological SynapseSoluble Cd6: SecretedThe Origins Of The Secreted Form Are Not ClearBut It Might Be Created By Proteolytic Shedding Of The Ectodomain |
| Alternative Protein Names | T-Cell Differentiation Antigen Cd6 proteinT12 proteinTp120 proteinCd Antigen Cd6 Cleaved Into - Soluble Cd6 proteinCD6 protein |
Information sourced from Uniprot.org
