Human CD363/S1PR1 protein (Recombinant) (N-GST & C-His) (STJP014446)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD363/S1PR1-N-GST & C-His protein was developed from e.coli and has a target region of N-GST & C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | S1PR1 |
| Gene ID | 1901 |
| Uniprot ID | S1PR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Tyr311-Ser382 |
Additional Info
| Post Translational Modifications | S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling. |
| Function | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. |
| Protein Name | Sphingosine 1-Phosphate Receptor 1S1p Receptor 1S1p1Endothelial Differentiation G-Protein Coupled Receptor 1Sphingosine 1-Phosphate Receptor Edg-1S1p Receptor Edg-1Cd Antigen Cd363 |
| Database Links | Reactome: R-HSA-419408Reactome: R-HSA-6785807Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosomeMembrane RaftRecruited To Caveolin-Enriched Plasma Membrane Microdomains In Response To Oxidized 1-Palmitoyl-2-Arachidonoyl-Sn-Glycero-3-PhosphocholineLigand Binding Leads To Receptor Internalization |
| Alternative Protein Names | Sphingosine 1-Phosphate Receptor 1 proteinS1p Receptor 1 proteinS1p1 proteinEndothelial Differentiation G-Protein Coupled Receptor 1 proteinSphingosine 1-Phosphate Receptor Edg-1 proteinS1p Receptor Edg-1 proteinCd Antigen Cd363 proteinS1PR1 proteinCHEDG1 proteinEDG1 protein |
Information sourced from Uniprot.org