Human CD35/CR1 protein (Recombinant) (N-His) (STJP004208)

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STJP004208
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD35/CR1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CR1
Gene ID: 1378
Uniprot ID: CR1_HUMAN
Immunogen Region: Ile1780-Pro2039
Immunogen: Homo sapiens (Human)
Function Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Protein Name Complement Receptor Type 1
C3b/C4b Receptor
Cd Antigen Cd35
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8877330
Reactome: R-HSA-977606
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Complement Receptor Type 1 protein
C3b/C4b Receptor protein
Cd Antigen Cd35 protein
CR1 protein
C3BR protein

Information sourced from Uniprot.org

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