Human CD344/FZD4 protein (Recombinant-Active) (C-hFc-His) (STJP012319)

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STJP012319-100
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Short Description :Recombinant-Active-Human CD344/FZD4-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity:Measured by its binding ability in a functional ELISA. In a 100 µL reaction mixture containing biotinylated rmWnt-5a at 100 ng/mL and rhCD344/FZD4 dilutions at 0.1-2, 000 ng/mL, the concentration of rhFrizzled-4/Fc Chimera that produces 50% of the op
Gene Symbol:FZD4
Gene ID:8322
Uniprot ID:FZD4_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Phe37-Glu180
Post Translational Modifications Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Function Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Protein Name Frizzled-4
Fz-4
Hfz4
Fze4
Cd Antigen Cd344
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-4086398
Reactome: R-HSA-4608870
Reactome: R-HSA-4641263
Reactome: R-HSA-5099900
Reactome: R-HSA-5340588
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Frizzled-4 protein
Fz-4 protein
Hfz4 protein
Fze4 protein
Cd Antigen Cd344 protein
FZD4 protein

Information sourced from Uniprot.org

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