| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | CD34 |
| Gene ID: | 947 |
| Uniprot ID: | CD34_HUMAN |
| Immunogen: | Recombinant Human CD34 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser32-Thr290) of human CD34 (Accession #NP_001020280.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | SLDNNGTATPELPTQGTFSN VSTNVSYQETTTPSTLGSTS LHPVSQHGNEATTNITETTV KFTSTSVITSVYGNTNSSVQ SQTSVISTVFTTPANVSTPE TTLKPSLSPGNVSDLSTTST SLATSPTKPYTSSSPILSDI KAEIKCSGIREVKLTQGICL EQNKTSSCAEFKKDRGEGLA RVLCGEEQADADAGAQVCSL LLAQSEVRPQCLLLVLANRT EISSKLQLMKKHQSDLKKL |
| Post Translational Modifications | Highly glycosylated. Phosphorylated on serine residues by PKC. |
| Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| Protein Name | Hematopoietic Progenitor Cell Antigen Cd34Cd Antigen Cd34 |
| Database Links | Reactome: R-HSA-198933 P28906-1 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Hematopoietic Progenitor Cell Antigen Cd34 proteinCd Antigen Cd34 proteinCD34 protein |
Information sourced from Uniprot.org