| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. |
| Protein Name | Fibroblast Growth Factor Receptor 2Fgfr-2K-SamKgfrKeratinocyte Growth Factor ReceptorCd Antigen Cd332 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-190375Reactome: R-HSA-190377Reactome: R-HSA-2023837Reactome: R-HSA-2033519Reactome: R-HSA-2219530Reactome: R-HSA-5654221Reactome: R-HSA-5654695Reactome: R-HSA-5654699Reactome: R-HSA-5654700Reactome: R-HSA-5654727Reactome: R-HSA-5655253Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-8851708Reactome: R-HSA-8853333 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusCytoplasmic VesicleDetected On Osteoblast Plasma Membrane Lipid RaftsAfter Ligand BindingThe Activated Receptor Is Rapidly Internalized And DegradedIsoform 1: Cell MembraneIsoform 3: Cell MembraneIsoform 8: SecretedIsoform 13: Secreted |
| Alternative Protein Names | Fibroblast Growth Factor Receptor 2 proteinFgfr-2 proteinK-Sam proteinKgfr proteinKeratinocyte Growth Factor Receptor proteinCd Antigen Cd332 proteinFGFR2 proteinBEK proteinKGFR proteinKSAM protein |
Information sourced from Uniprot.org
