Human CD328/SIGLEC7 protein (Recombinant) (C-His) (STJP013615)

Name: Human CD328/SIGLEC7 protein (Recombinant) (C-His) (STJP013615)
SKU: STJP013615-100
Price: 648.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP013615-100

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Short Description	Recombinant-Human CD328/SIGLEC7-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Post Translational Modifications	Tyrosine phosphorylated.
Function	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Protein Name	Sialic Acid-Binding Ig-Like Lectin 7 Siglec-7 Adhesion Inhibitory Receptor Molecule 1 Airm-1 Cdw328 D-Siglec Qa79 Membrane Protein P75 Cd Antigen Cd328
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Sialic Acid-Binding Ig-Like Lectin 7 protein Siglec-7 protein Adhesion Inhibitory Receptor Molecule 1 protein Airm-1 protein Cdw328 protein D-Siglec protein Qa79 Membrane Protein protein P75 protein Cd Antigen Cd328 protein SIGLEC7 protein AIRM1 protein

Information sourced from Uniprot.org