Human CD320 protein (Recombinant) (C-His) (STJP001979)

Human CD320 protein (Recombinant) (C-His) (STJP001979)

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STJP001979
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/Mu g
Gene Symbol: PTK7
Gene ID: 5754
Uniprot ID: PTK7_HUMAN
Immunogen Region: Ala31-Thr704
Immunogen: Recombinant Human CD320 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala31-Thr704) of human CD320 (Accession #NP_002812.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: SPLSTPTSAQAAGPSSGSCP PTKFQCRTSGLCVPLTWRCD RDLDCSDGSDEEECRIEPCT QKGQCPPPPGLPCPCTGVSD CSGGTDKKLRNCSRLACLAG ELRCTLSDDCIPLTWRCDGH PDCPDSSDELGCGTNEILPE GDATTMGPPVTLESVTSLRN ATTMGPPVTLESVPSVGNAT SSSAGDQSGSPTAYGV
Post Translational Modifications MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Function Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Protein Name Inactive Tyrosine-Protein Kinase 7
Colon Carcinoma Kinase 4
Cck-4
Protein-Tyrosine Kinase 7
Pseudo Tyrosine Kinase Receptor 7
Tyrosine-Protein Kinase-Like 7
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Colocalizes With Mmp14 At Cell Junctions
Also Localizes At The Leading Edge Of Migrating Cells
Alternative Protein Names Inactive Tyrosine-Protein Kinase 7 protein
Colon Carcinoma Kinase 4 protein
Cck-4 protein
Protein-Tyrosine Kinase 7 protein
Pseudo Tyrosine Kinase Receptor 7 protein
Tyrosine-Protein Kinase-Like 7 protein
PTK7 protein
CCK4 protein

Information sourced from Uniprot.org

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