Human CD292/BMPR1A protein (Recombinant-Active) (C-hFc-His) (STJP011979)

SKU:
STJP011979-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CD292/BMPR1A-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: BMPR1A
Gene ID: 657
Uniprot ID: BMR1A_HUMAN
Immunogen Region: Gln24-Arg152
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated.
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2.
Protein Name Bone Morphogenetic Protein Receptor Type-1a
Bmp Type-1a Receptor
Bmpr-1a
Activin Receptor-Like Kinase 3
Alk-3
Serine/Threonine-Protein Kinase Receptor R5
Skr5
Cd Antigen Cd292
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Surface
Alternative Protein Names Bone Morphogenetic Protein Receptor Type-1a protein
Bmp Type-1a Receptor protein
Bmpr-1a protein
Activin Receptor-Like Kinase 3 protein
Alk-3 protein
Serine/Threonine-Protein Kinase Receptor R5 protein
Skr5 protein
Cd Antigen Cd292 protein
BMPR1A protein
ACVRLK3 protein
ALK3 protein

Information sourced from Uniprot.org

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