• Human CD28 protein (Recombinant) (C-His) (STJP000911)
  • Human CD28 protein (Recombinant) (C-His) (STJP000911)
  • Human CD28 protein (Recombinant) (C-His) (STJP000911)
  • Human CD28 protein (Recombinant) (C-His) (STJP000911)

Human CD28 protein (Recombinant) (C-His) (STJP000911)

SKU:
STJP000911

£59.50 - £156.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD28-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CD28 Protein at 1 Mu g/mL (100 Mu L/well) can bind CD28 Rabbit mAb with a linear range of 0.06-1.04 ng/mL.
Gene Symbol: CD28
Gene ID: 940
Uniprot ID: CD28_HUMAN
Immunogen Region: Asn19-Pro152
Immunogen: Recombinant Human CD28 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asn19-Pro152) of human CD28/TP44 (Accession #NP_006130.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Expressed in T-cells and plasma cells, but not in less mature B-cells.
Post Translational Modifications CD40LG induces tyrosine phosphorylation of isoform 3.
Function Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Protein Name T-Cell-Specific Surface Glycoprotein Cd28
Tp44
Cd Antigen Cd28
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-164939
Reactome: R-HSA-2219530
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-6811558
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Isoform 3: Cell Surface
Alternative Protein Names T-Cell-Specific Surface Glycoprotein Cd28 protein
Tp44 protein
Cd Antigen Cd28 protein
CD28 protein

Information sourced from Uniprot.org

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