| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human CD265/TNFRSF11A/RANK-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit TRANCE-induced osteoclast differentiation of mouse monocyte/macrophage cells (RAW 264.7). The ED50 for this effect is 0.005‑0.035 µg/mL in the presence of 2 ng/mL of rmTRANCE. |
| Gene Symbol: | TNFRSF11A |
| Gene ID: | 8792 |
| Uniprot ID: | TNR11_HUMAN |
| Immunogen Region: | Gln29-Gly213 |
| Immunogen: | Homo sapiens (Human) |
| Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL.essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11aOsteoclast Differentiation Factor ReceptorOdfrReceptor Activator Of Nf-KbCd Antigen Cd265 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftIsoform Rank-E5a: Cell Membrane |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 11a proteinOsteoclast Differentiation Factor Receptor proteinOdfr proteinReceptor Activator Of Nf-Kb proteinCd Antigen Cd265 proteinTNFRSF11A proteinRANK protein |
Information sourced from Uniprot.org