Human CD24 protein (Recombinant) (C-Llama Fc) (STJP020025)

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STJP020025
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: CD24
Gene ID: 100133941
Uniprot ID: CD24_HUMAN
Immunogen Region: Ser27-Gly59
Immunogen: Recombinant Human CD24 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Gly59) of Human CD24 (Accession #P25063) fused with a C-Llama Fc tag at the C-terminus.
Immunogen Sequence: SETTTGTSSNSSQSTSNSGL APNPTNATTKAAG
Tissue Specificity B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
Post Translational Modifications Extensively O-glycosylated.
Function May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
Protein Name Signal Transducer Cd24
Small Cell Lung Carcinoma Cluster 4 Antigen
Cd Antigen Cd24
Database Links Reactome: R-HSA-373760
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Signal Transducer Cd24 protein
Small Cell Lung Carcinoma Cluster 4 Antigen protein
Cd Antigen Cd24 protein
CD24 protein
CD24A protein

Information sourced from Uniprot.org

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