Human CD200R1 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020242)

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STJP020242-100
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Short Description :Recombinant-Human CD200R1-C-His&Avi protein was developed in hek293 cells using the region Ala27-Leu266. For use in research applications.
Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Formulation:Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:< 1 EU/Mu g of the protein by LAL method.
Gene Symbol:CD200R1
Gene ID:131450
Uniprot ID:MO2R1_HUMAN
Immunogen:Biotinylated Recombinant Human CD200R1 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala27-Leu266) of Human CD200R1 fused with a His and Avi tag at the C-terminal.
Immunogen Region:Ala27-Leu266
Tissue Specificity Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.
Function Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Protein Name Cell Surface Glycoprotein Cd200 Receptor 1
Cd200 Cell Surface Glycoprotein Receptor
Cell Surface Glycoprotein Ox2 Receptor 1
Database Links Reactome: R-HSA-198933
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 4: Cell Membrane
Isoform 2: Secreted
Isoform 3: Secreted
Alternative Protein Names Cell Surface Glycoprotein Cd200 Receptor 1 protein
Cd200 Cell Surface Glycoprotein Receptor protein
Cell Surface Glycoprotein Ox2 Receptor 1 protein
CD200R1 protein
CD200R protein
CRTR2 protein
MOX2R protein
OX2R protein
UNQ2522 protein
PRO6015 protein

Information sourced from Uniprot.org

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