Human CD191/CCR1 protein (Recombinant) (N-GST) (STJP004560)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD191/CCR1-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CCR1 |
| Gene ID | 1230 |
| Uniprot ID | CCR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln265-Leu281 |
Additional Info
| Function | Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway. |
| Protein Name | C-C Chemokine Receptor Type 1C-C Ckr-1Cc-Ckr-1Ccr-1Ccr1Hm145Ld78 ReceptorMacrophage Inflammatory Protein 1-Alpha ReceptorMip-1alpha-RRantes-RCd Antigen Cd191 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | C-C Chemokine Receptor Type 1 proteinC-C Ckr-1 proteinCc-Ckr-1 proteinCcr-1 proteinCcr1 proteinHm145 proteinLd78 Receptor proteinMacrophage Inflammatory Protein 1-Alpha Receptor proteinMip-1alpha-R proteinRantes-R proteinCd Antigen Cd191 proteinCCR1 proteinCMKBR1 proteinCMKR1 proteinSCYAR1 protein |
Information sourced from Uniprot.org