| Post Translational Modifications | Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels. |
| Function | Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. |
| Protein Name | B-Lymphocyte Antigen Cd19B-Lymphocyte Surface Antigen B4Differentiation Antigen Cd19T-Cell Surface Antigen Leu-12Cd Antigen Cd19 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-198933Reactome: R-HSA-2219530Reactome: R-HSA-6811558Reactome: R-HSA-977606Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Protein Names | B-Lymphocyte Antigen Cd19 proteinB-Lymphocyte Surface Antigen B4 proteinDifferentiation Antigen Cd19 proteinT-Cell Surface Antigen Leu-12 proteinCd Antigen Cd19 proteinCD19 protein |
Information sourced from Uniprot.org
