Human CD172a/SIRPA protein (Recombinant) (C-His) (STJP006639)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD172a/SIRPA-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SIRPA |
| Gene ID | 140885 |
| Uniprot ID | SHPS1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg370 |
Additional Info
| Post Translational Modifications | N-glycosylated. Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. |
| Function | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1Shp Substrate 1Shps-1Brain Ig-Like Molecule With Tyrosine-Based Activation MotifsBitCd172 Antigen-Like Family Member AInhibitory Receptor Shps-1Macrophage Fusion ReceptorMyd-1 AntigenSignal-Regulatory Protein Alpha-1Sirp-Alpha-1Signal-Regulatory Protein Alpha-2Sirp-Alpha-2Signal-Regulatory Protein Alpha-3Sirp-Alpha-3P84Cd Antigen Cd172a |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-391160Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 proteinShp Substrate 1 proteinShps-1 proteinBrain Ig-Like Molecule With Tyrosine-Based Activation Motifs proteinBit proteinCd172 Antigen-Like Family Member A proteinInhibitory Receptor Shps-1 proteinMacrophage Fusion Receptor proteinMyd-1 Antigen proteinSignal-Regulatory Protein Alpha-1 proteinSirp-Alpha-1 proteinSignal-Regulatory Protein Alpha-2 proteinSirp-Alpha-2 proteinSignal-Regulatory Protein Alpha-3 proteinSirp-Alpha-3 proteinP84 proteinCd Antigen Cd172a proteinSIRPA proteinBIT proteinMFR proteinMYD1 proteinPTPNS1 proteinSHPS1 proteinSIRP protein |
Information sourced from Uniprot.org