| Function | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl4Cd158 Antigen-Like Family Member DG9pKiller Cell Inhibitory Receptor 103asKir-103asMhc Class I Nk Cell Receptor Kir103asCd Antigen Cd158d |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEarly Endosome Membrane |
| Alternative Protein Names | Killer Cell Immunoglobulin-Like Receptor 2dl4 proteinCd158 Antigen-Like Family Member D proteinG9p proteinKiller Cell Inhibitory Receptor 103as proteinKir-103as proteinMhc Class I Nk Cell Receptor Kir103as proteinCd Antigen Cd158d proteinKIR2DL4 proteinCD158D proteinKIR103AS protein |
Information sourced from Uniprot.org
