• Biotinylated Human CD155 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
  • The purity of Biotinylated Human CD155 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Biotinylated Human CD155, His Tag at 1 Mu g/ml (100 Mu l/well) on the streptavidin precoated plate (5 Mu g/ml). Dose response curve for Human TIGIT, hFc Tag with the EC50 of 4. 3ng/ml determined by ELISA.

Human CD155/PVR protein (Recombinant) (C-His-Avi) {Biotin} (STJP001755)

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STJP001755

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD155/PVR-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: PVR
Gene ID: 5817
Uniprot ID: PVR_HUMAN
Immunogen Region: Trp21-Asn343
Immunogen: DNA sequence encoding Human CD155/PVR including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Protein Name Poliovirus Receptor
Nectin-Like Protein 5
Necl-5
Cd Antigen Cd155
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-420597
Cellular Localisation Isoform Alpha: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Delta: Cell Membrane
Isoform Beta: Secreted
Isoform Gamma: Secreted
Alternative Protein Names Poliovirus Receptor protein
Nectin-Like Protein 5 protein
Necl-5 protein
Cd Antigen Cd155 protein
PVR protein
PVS protein

Information sourced from Uniprot.org

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