Human CD152/CTLA4 protein (Recombinant-Active) (C-GST) (STJP012493)

Name: Human CD152/CTLA4 protein (Recombinant-Active) (C-GST) (STJP012493)
SKU: STJP012493-100
Price: 414.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP012493-100

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Short Description	Recombinant-Active-Human CD152/CTLA4-C-GST protein was developed from mammalian cells and has a target region of C-GST. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Post Translational Modifications	N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Function	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Protein Name	Cytotoxic T-Lymphocyte Protein 4 Cytotoxic T-Lymphocyte-Associated Antigen 4 Ctla-4 Cd Antigen Cd152
Database Links	Reactome: R-HSA-389356 Reactome: R-HSA-389513 Reactome: R-HSA-8877330
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Exists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization
Alternative Protein Names	Cytotoxic T-Lymphocyte Protein 4 protein Cytotoxic T-Lymphocyte-Associated Antigen 4 protein Ctla-4 protein Cd Antigen Cd152 protein CTLA4 protein CD152 protein

Information sourced from Uniprot.org