Human CD148/PTPRJ protein (Recombinant) (N-His) (STJP005270)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD148/PTPRJ-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PTPRJ |
| Gene ID | 5795 |
| Uniprot ID | PTPRJ_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg997-Ala1337 |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. Isoform 2: N-glycosylated. |
| Function | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Has a role in megakaryocytes and platelet formation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration.through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation.through KDR dephosphorylation. Negative regulator of EGFR signaling pathway.through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Isoform 2: Activates angiogenesis and cell migration. Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase EtaProtein-Tyrosine Phosphatase EtaR-Ptp-EtaDensity-Enhanced Phosphatase 1Dep-1Hptp EtaProtein-Tyrosine Phosphatase Receptor Type JR-Ptp-JCd Antigen Cd148 |
| Database Links | Reactome: R-HSA-202427Reactome: R-HSA-6798695Reactome: R-HSA-6807004Reactome: R-HSA-9706369 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionRuffle MembraneCell JunctionAfter T-Cell StimulationIt Is Temporarily Excluded From Immunological SynapsesIsoform 2: SecretedExtracellular Space |
| Alternative Protein Names | Receptor-Type Tyrosine-Protein Phosphatase Eta proteinProtein-Tyrosine Phosphatase Eta proteinR-Ptp-Eta proteinDensity-Enhanced Phosphatase 1 proteinDep-1 proteinHptp Eta proteinProtein-Tyrosine Phosphatase Receptor Type J proteinR-Ptp-J proteinCd Antigen Cd148 proteinPTPRJ proteinDEP1 protein |
Information sourced from Uniprot.org