Human CD148/PTPRJ protein (Recombinant) (N-His) (STJP005270)

SKU:
STJP005270
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD148/PTPRJ-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTPRJ
Gene ID: 5795
Uniprot ID: PTPRJ_HUMAN
Immunogen Region: Arg997-Ala1337
Immunogen: Homo sapiens (Human)
Post Translational Modifications N- and O-glycosylated. Isoform 2: N-glycosylated.
Function Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Has a role in megakaryocytes and platelet formation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration.through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation.through KDR dephosphorylation. Negative regulator of EGFR signaling pathway.through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Isoform 2: Activates angiogenesis and cell migration. Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase Eta
Protein-Tyrosine Phosphatase Eta
R-Ptp-Eta
Density-Enhanced Phosphatase 1
Dep-1
Hptp Eta
Protein-Tyrosine Phosphatase Receptor Type J
R-Ptp-J
Cd Antigen Cd148
Database Links Reactome: R-HSA-202427
Reactome: R-HSA-6798695
Reactome: R-HSA-6807004
Reactome: R-HSA-9706369
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Ruffle Membrane
Cell Junction
After T-Cell Stimulation
It Is Temporarily Excluded From Immunological Synapses
Isoform 2: Secreted
Extracellular Space
Alternative Protein Names Receptor-Type Tyrosine-Protein Phosphatase Eta protein
Protein-Tyrosine Phosphatase Eta protein
R-Ptp-Eta protein
Density-Enhanced Phosphatase 1 protein
Dep-1 protein
Hptp Eta protein
Protein-Tyrosine Phosphatase Receptor Type J protein
R-Ptp-J protein
Cd Antigen Cd148 protein
PTPRJ protein
DEP1 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP008460 Human CYP2E1 protein (Recombinant) (N-His) (STJP008460) E. coli
STJP008467 Human IKZF1 protein (Recombinant) (N-His) (STJP008467) E. coli
STJP008520 Human TAF1 protein (Recombinant) (N-His) (STJP008520) E. coli

Related Products

!