Human CCL5/RANTES protein (Recombinant) (C-hFC) (STJP003014)

SKU:
STJP003014

£123.50 - £464.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Supplied as a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CCL5 at 5 Mu g/mL (100 Mu L/well) can bind Mouse CXCL4 with a linear range of 10-252.6 ng/mL.
Gene Symbol: CCL5
Gene ID: 6352
Uniprot ID: CCL5_HUMAN
Immunogen Region: Ser24-Ser91
Immunogen: Recombinant Human CCL5/RANTES Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser24-Ser91) of human CCL5/RANTES (Accession #NP_002976.2) fused with and a 6×His tag at the C-terminus.
Immunogen Sequence: SLEPVYWNSANKRFQAEGGY VLYPQIGDRLDLLCPRARPP GPHSSPSYEFYKLYLVEGAQ GRRCEAPPAPNLLLTCDRPD LDLRFTIKFQEYSPNLWGHE FRSHHDYYIIATSDGTREGL ESLQGGVCLTRGMKVLLRVG QSPRGGAVPRKPVSEMPMER DRGAAHSAEPGRDTIPGDPS SNATSRGAEGPLPPPSMPA
Tissue Specificity Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Post Translational Modifications N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Protein Name C-C Motif Chemokine 5
Eocp
Eosinophil Chemotactic Cytokine
Sis-Delta
Small-Inducible Cytokine A5
T Cell-Specific Protein P228
Tcp228
T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 5 protein
Eocp protein
Eosinophil Chemotactic Cytokine protein
Sis-Delta protein
Small-Inducible Cytokine A5 protein
T Cell-Specific Protein P228 protein
Tcp228 protein
T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68 protein
CCL5 protein
D17S136E protein
SCYA5 protein

Information sourced from Uniprot.org

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