Name: Human CCL4/MIP-1Beta protein (Recombinant) (C-hFc) (STJP002858)
SKU: STJP002858
Availability: InStock

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g

Gene Symbol:	CCL4
Gene ID:	388372/6351
Uniprot ID:	CCL4_HUMAN
Immunogen Region:	Ala24-Asn92
Immunogen:	Recombinant Human CCL4/MIP-1Beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Asn92) of human CCL4/MIP-1Beta (Accession #NP_002975.1) fused with and a hFc tag at the C-terminus.
Immunogen Sequence:	APMGSDPPTACCFSYTARKL PRNFVVDYYETSSLCSQPAV VFQTKRSKQVCADPSESWVQ EYVYDLELN

Function	Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Protein Name	C-C Motif Chemokine 4 G-26 T-Lymphocyte-Secreted Protein Hc21 Lymphocyte Activation Gene 1 Protein Lag-1 Mip-1-Beta(1-69 Macrophage Inflammatory Protein 1-Beta Mip-1-Beta Pat 744 Protein H400 Sis-Gamma Small-Inducible Cytokine A4 T-Cell Activation Protein 2 Act-2 Cleaved Into - Mip-1-Beta(3-69
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Secreted
Alternative Protein Names	C-C Motif Chemokine 4 protein G-26 T-Lymphocyte-Secreted Protein protein Hc21 protein Lymphocyte Activation Gene 1 Protein protein Lag-1 protein Mip-1-Beta(1-69 protein Macrophage Inflammatory Protein 1-Beta protein Mip-1-Beta protein Pat 744 protein Protein H400 protein Sis-Gamma protein Small-Inducible Cytokine A4 protein T-Cell Activation Protein 2 protein Act-2 Cleaved Into - Mip-1-Beta(3-69 protein CCL4 protein LAG1 protein MIP1B protein SCYA4 protein

Information sourced from Uniprot.org

Human CCL4/MIP-1Beta protein (Recombinant) (C-hFc) (STJP002858)