Human CCL4/MIP-1Beta protein (Recombinant) (C-hFc) (STJP002858)

SKU:
STJP002858

£72.50 - £273.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CCL4/MIP-1Beta-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCL4
Gene ID: 388372/6351
Uniprot ID: CCL4_HUMAN
Immunogen Region: Ala24-Asn92
Immunogen: Recombinant Human CCL4/MIP-1Beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Asn92) of human CCL4/MIP-1Beta (Accession #NP_002975.1) fused with and a hFc tag at the C-terminus.
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Protein Name C-C Motif Chemokine 4
G-26 T-Lymphocyte-Secreted Protein
Hc21
Lymphocyte Activation Gene 1 Protein
Lag-1
Mip-1-Beta(1-69
Macrophage Inflammatory Protein 1-Beta
Mip-1-Beta
Pat 744
Protein H400
Sis-Gamma
Small-Inducible Cytokine A4
T-Cell Activation Protein 2
Act-2 Cleaved Into - Mip-1-Beta(3-69
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 4 protein
G-26 T-Lymphocyte-Secreted Protein protein
Hc21 protein
Lymphocyte Activation Gene 1 Protein protein
Lag-1 protein
Mip-1-Beta(1-69 protein
Macrophage Inflammatory Protein 1-Beta protein
Mip-1-Beta protein
Pat 744 protein
Protein H400 protein
Sis-Gamma protein
Small-Inducible Cytokine A4 protein
T-Cell Activation Protein 2 protein
Act-2 Cleaved Into - Mip-1-Beta(3-69 protein
CCL4 protein
LAG1 protein
MIP1B protein
SCYA4 protein

Information sourced from Uniprot.org

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