Function | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
Protein Name | C-C Motif Chemokine 216ckineBeta-Chemokine Exodus-2Secondary Lymphoid-Tissue ChemokineSlcSmall-Inducible Cytokine A21 |
Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
Cellular Localisation | Secreted |
Alternative Protein Names | C-C Motif Chemokine 21 protein6ckine proteinBeta-Chemokine Exodus-2 proteinSecondary Lymphoid-Tissue Chemokine proteinSlc proteinSmall-Inducible Cytokine A21 proteinCCL21 proteinSCYA21 proteinUNQ784 proteinPRO1600 protein |
Information sourced from Uniprot.org