Human CCL14/NCC-2 protein (Recombinant) (N-GST) (STJP005498)

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STJP005498
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CCL14/NCC-2-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CCL14
Gene ID: 6358
Uniprot ID: CCL14_HUMAN
Immunogen Region: Thr20-Asn93
Immunogen: Homo sapiens (Human)
Post Translational Modifications The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated.the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
Function Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Protein Name C-C Motif Chemokine 14
Chemokine Cc-1/Cc-3
Hcc-1/Hcc-3
Hcc-1(1-74
Ncc-2
Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 14 protein
Chemokine Cc-1/Cc-3 protein
Hcc-1/Hcc-3 protein
Hcc-1(1-74 protein
Ncc-2 protein
Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 protein
CCL14 protein
NCC2 protein
SCYA14 protein

Information sourced from Uniprot.org

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