Human CCL14/NCC-2 protein (Recombinant) (C-His) (STJP013491)

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STJP013491-100
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Short Description :Recombinant-Human CCL14/NCC-2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.2.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:CCL14
Gene ID:6358
Uniprot ID:CCL14_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Thr20-Asn93
Post Translational Modifications The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated.the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
Function Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Protein Name C-C Motif Chemokine 14
Chemokine Cc-1/Cc-3
Hcc-1/Hcc-3
Hcc-1(1-74
Ncc-2
Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74
Database Links
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 14 protein
Chemokine Cc-1/Cc-3 protein
Hcc-1/Hcc-3 protein
Hcc-1(1-74 protein
Ncc-2 protein
Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 protein
CCL14 protein
NCC2 protein
SCYA14 protein

Information sourced from Uniprot.org

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