Human CCDC134 protein (Recombinant) (C-His) (STJP013749)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CCDC134-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CCDC134 |
| Gene ID | 79879 |
| Uniprot ID | CC134_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr23-Leu229 |
Additional Info
| Post Translational Modifications | O-glycosylated, with additional sialic acid modifications. |
| Function | Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development. |
| Protein Name | Coiled-Coil Domain-Containing Protein 134 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum LumenSecretedCytoplasmNucleusMainly Localizes To The Endoplasmic ReticulumAccumulates In The Nucleus In Response To Uv Irradiation |
| Alternative Protein Names | Coiled-Coil Domain-Containing Protein 134 proteinCCDC134 protein |
Information sourced from Uniprot.org